Plasmonic Nanoprobes for Real-Time Optical Monitoring of Nitric Oxide inside Living Cells

Pilar Rivera-Gil, Carmen Vázquez-Vázquez, Vincenzo Giannini, M. Pilar Callao, Wolfgang J. Parak, Miguel A. Correa-Duarte, and Ramón A. Álvarez-Puebla
Angew. Chem. Int. Ed., 2013, 52, 13694–13698


An optical sensor was developed for the quantitative determination of intracellular nitric oxide. The sensor consists of plasmonic nanoprobes (see picture, left) that have a coating of mesoporous silica and an inner gold island film functionalized with a chemoreceptor for NO.