Controlled Drug Delivery Systems for Cancer Based on Mesoporous Silica Nanoparticles

Nerea Iturrioz-Rodríguez, Miguel A. Correa-Duarte, and Mónica L. Fanarraga

Int. J. Nanomed. 2019, 14, 3389‒3401

The implementation of nanotechnology in medicine has opened new research horizons particularly in the field of therapeutic delivery. Mesoporous silica particles have emerged as biocompatible drug delivery systems with an enormous potential in the treatment of cancer among many other pathologies. In this review, we focus on the unique properties of these particles as chemotherapy delivery carriers. Here, we summarize the general characteristics of these nanomaterials – including their physicochemical properties and customizable surfaces – different stimuli that can be used to trigger targeted drug release, biocompatibility and finally, the drawbacks of these types of nanomaterials, highlighting some of the most important features of mesoporous silica nanoparticles in drug delivery.